Two sample MR report
RRP7A_Alveolar Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.5116602 | 0.6461221 | 0.4643167 |
| Weighted median | 7 | -0.1022323 | 0.0295946 | 0.0005515 |
| Inverse variance weighted | 7 | -0.0726277 | 0.0326037 | 0.0259080 |
| Simple mode | 7 | -0.1034368 | 0.0362422 | 0.0290275 |
| Weighted mode | 7 | -0.1028296 | 0.0355476 | 0.0275950 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 11.77057 | 5 | 0.0380704 |
| Inverse variance weighted | 13.70073 | 6 | 0.0331638 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.3961217 | 0.4374672 | 0.406722 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.91e-05 | 0 | TRUE | 0.4694855 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
